RNAP-σ interaction-IN-4

SKU: orb3174488

Description

RNAP-σ interaction-IN-4 (Compound 3a) is an inhibitor of the interaction between RNA polymerase and the sigma factor (RNAP-σ). It has a minimum inhibitory concentration (MIC) of 1 μg/mL against S. pneumoniae and 2 μg/mL against S. aureus. This compound exhibits potent bactericidal properties by disrupting bacterial transcription through interference with the β′CH−σ interaction. Additionally, RNAP-IN-2 has demonstrated significant efficacy in a sepsis model. RNAP-σ interaction-IN-4 is applicable for studying Gram-positive bacterial infections involving multidrug-resistant strains.

Research Area

Cell Biology, Infectious Disease & Virology, Molecular Biology

Key Properties

• Target: DNA/RNA Synthesis,Antibacterial

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

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Gene Symbol

DNA/RNA Synthesis,Antibacterial