RN-1 dihydrochloride

SKU: orb1306256

Description

RN-1 dihydrochloride is a potent, selective, and irreversible inhibitor of lysine-specific demethylase 1 (LSD1) with an IC50 of 70 nM. This compound is a valuable chemical probe for epigenetic research, enabling the study of LSD1's role in cancer biology and other diseases in both cellular and animal models.

Research Area

Epigenetics & Chromatin, Metabolism Research, Neuroscience

Key Properties

• CAS Number: 1781835-13-9
• MW: 452.42
• Purity: 99.64% (May vary between batches)
• Formula: C₂₃H₃₁Cl₂N₃O₂
• SMILES: Cl.Cl.CN1CCN(CC1)C(=O)CN[C@H]1C[C@@H]1c1ccc(OCc2ccccc2)cc1
• Target: Histone Demethylase,MAO
• Solubility: H2O:18 mg/mL (39.79 mM)

Bioactivity

• Target IC50:
  MAO-A:0.51 μM|LSD1:70 nM|MAO-B:2.785 μM
• In Vivo:
  In sickle cell disease (SCD) mice, RN-1 dihydrochloride (3-10 mg/kg; i.p.) effectively induces fetal hemoglobin (HbF) levels in red blood cells and reduces disease pathology. In C57BL/6 male mice, after administration of RN-1 dihydrochloride (10 mg/kg, i.p.), concentrations are detectable up to 24 h post dose in both plasma and brain tissues. RN-1 dihydrochloride significantly impairs long-term memory, but not short-term memory. The brain/plasma exposure ratio is 88.9.
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• In Vitro:
  RN-1 dihydrochloride exhibits selectivity for LSD1 over MAO-A and MAO-B with IC50 values of 0.51 μM and 2.785 μM respectively.

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

sickle, RN1, RN-1, RN1 dihydrochloride, RN1 Dihydrochloride, RN-1 Dihydrochloride, RN 1, RN 1 dihydrochloride, RN 1 Dihydrochloride, brain-penetrant, disease, cell, inhibit, irreversible, LSD1, hemoglobin, HbF, Inhibitor, HistoneDemethylase, Histone Demethylase, MAO-B, MAO-A, fetal

Compound Identifiers

PubChem CID

129626553