RN-0001

SKU: orb3212333

Description

RN-0001 is a cyclophilin (Cyp) inhibitor with a Ki of 4.1 nM for CypA and 12.0 nM for CypD, and an EC50 of 916 nM for CypD. It binds directly to CypD, inhibiting the peptidyl-prolyl cis-trans isomerase activity of both CypD and CypA, and prevents CypD-dependent mitochondrial permeability transition pore opening. RN-0001 enhances mitochondrial function, reduces ROS production and apoptosis, prevents NF-κBp65 nuclear translocation, and decreases the release of activated caspase-3 and cytochrome c. This compound is applicable in the study of alcohol-related liver diseases.

Key Properties

• Target: Caspase,ROS,NF-κB,Apoptosis
• CAS Number: 252731-57-0
• MW: 1289.73
• Formula: C₆₆H₁₂₀N₁₂O₁₃
• SMILES: [C@H]([C@@H](C/C=C/C)C)(O)[C@@]1(N(C)C(=O)[C@H](C(C)C)N(C)C(=O)[C@H](CC(C)C)N(C)C(=O)[C@H](CC(C)C)N(C)C(=O)[C@@H](C)NC(=O)[C@H](C)NC(=O)[C@H](CC(C)C)N(C)C(=O)[C@H](C(C)C)NC(=O)[C@H](CC(C)C)N(C)C(=O)[C@@H](OCCN(C)C)N(C)C(=O)[C@H](CC)NC1=O)[H]

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Quick Database Links

Gene Symbol

Caspase,ROS,NF-κB,Apoptosis