RMC-9945

SKU: orb3173905

Description

RMC-9945 (RM-044) is a KRAS inhibitor that is selective, covalent, and orally active against the RAS(ON) G12D mutation. It enhances the transcriptional activity of β-Catenin/TCF and demonstrates sustained disease control in early liver metastasis models of colorectal cancer.

Research Area

Signal Transduction, Stem Cell & Developmental Biology

Key Properties

• CAS Number: 2922732-38-3
• MW: 1140.43
• Formula: C₆₀H₈₀F₃N₁₁O₆S
• SMILES: O=C1OCC(C)(C)CC=2C3=CC(=CC=C3N(C2C4=CC(=CN=C4C(OC)C)N5CCN(CC5)C6CC6)CC(F)(F)F)C=7N=C(SC7)CC(NC(=O)C(N8CCC9(CN(C(=O)C%10N(C)C%10C%11CC%11)CC9)C8)C(C)C)C(=O)N%12NC1CCC%12
• Target: Ras,Wnt/beta-catenin

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Quick Database Links

Gene Symbol

Ras,Wnt/beta-catenin