RMC-6291

SKU: orb1982293

Description

RMC-6291 is a potent, orally bioavailable KRASG12C(ON) inhibitor that exerts its antitumor effect by spatially blocking effector binding to prevent downstream ERK signaling. It induces apoptosis in KRASG12C-mutant cell lines like H358 and shows activity in preclinical in vivo models, supporting its investigation in oncology research.

Research Area

Cell Biology, Pharmacology & Drug Discovery, Signal Transduction

Key Properties

• CAS Number: 2641998-63-0
• MW: 1012.26
• Purity: 99.92% (May vary between batches)
• Formula: C₅₅H₇₈FN₉O₈
• SMILES: O=C(C#CC(N(C)C)(C)C)N1CCC(F)(C(=O)N(C)C(C(=O)NC2C(=O)N3NC(C(=O)OCC(C)(C)CC=4C5=CC(=CC=C5N(C4C=6C=CC=NC6C(OC)C)CC)N7CCOC(C7)C2)CCC3)C(C)C)CC1
• Target: Apoptosis,Kras,Ras,ERK
• Solubility: DMSO:80 mg/mL (79.03 mM);10% DMSO+90% Corn Oil:3.3 mg/mL (3.26 mM)

Bioactivity

• In Vivo:
  RMC-6291 (200mg/kg, orally, once daily, for 60 days) significantly inhibits tumor growth and induces immune memory in mouse tumor models.

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

RMC6291, RMC 6291, 2775304-30-6, Apoptosis, KRAS G12C

Compound Identifiers

PubChem CID

169492905