RM-055

SKU: orb3177581

Description

RM-055 is a novel catalytic RAS(ON) inhibitor that accelerates RAS-GTP hydrolysis by mimicking GAP activity, promoting the transition from RAS(ON) to RAS(OFF). Forming a non-covalent complex with CYPA, RM-055 potently inhibits oncogenic RAS signaling and demonstrates significant and sustained antitumor activity across various G12-mutant tumor models, including those resistant to daraxonrasib.

Research Area

Signal Transduction

Key Properties

• MW: 656.78
• Formula: C₃₆H₄₇F₃N₄O₄
• SMILES: CCCCCCC/C=C/C=C/C(NCCC1=CC=C(OC)C(OCCCCCCNC(C2=CC=C(C3(N=N3)C(F)(F)F)C=C2)=O)=C1)=O
• Target: Ras,Kras

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Quick Database Links

Gene Symbol

Ras,Kras