Ritonavir

SKU: orb1308324

Description

Ritonavir

Research Area

Cell Biology, Infectious Disease & Virology, Protein Biochemistry

Key Properties

• CAS Number: 155213-67-5
• MW: 720.94
• Purity: 99.86%
• Formula: C₃₇H₄₈N₆O₅S₂
• SMILES: CC(C)[C@H](NC(=O)N(C)CC1=CSC(=N1)C(C)C)C(=O)N[C@H](C[C@H](O)[C@H](CC1=CC=CC=C1)NC(=O)OCC1=CN=CS1)CC1=CC=CC=C1
• Target: HIV Protease,Apoptosis,SARS-CoV
• Solubility: Ethanol:7.21 mg/mL (10 mM);DMSO:242.5 mg/mL (336.37 mM);10% DMSO+90% Corn Oil:2.5 mg/mL (3.47 mM)

Bioactivity

• In Vivo:
  Ritonavir is a potent inhibitor of CYP3A-mediated biotransformation (terfenadine hydroxylation, IC50 of 0.14 mM; 17alpha-ethynylestradiol 2-hydroxylation, IC50 of 2 mM; nifedipine oxidation, IC50 of 0.07 mM).Ritonavir is a a potent inhibitor of CYP3A4-mediated testicular 6β-hydroxylation (Ki: 19 nM), and also inhibited hydroxylation by toluenesulfonylurea (IC50: 4.2 μM).Ritonavir also inhibited CYP2D6 (IC50: 2.5 mM) and CYP2C9/10 (IC50: 8.0 mM)-mediated responses.Ritonavir Ritonavir increased the cellular activity of uninfected human PBMC cultures.Ritonavir inhibited p-glycoprotein-mediated saquinavir solubilization (IC50: 0.2 μM), suggesting that Ritonavir has a high affinity for p-glycoprotein.Ritonavir significantly inhibited the metabolism of human hepatic microsomes ABT-378 (Ki: 13 nM). Ritonavir binding to ABT-378 ( in 3:1 and 29:1 ratios) was able to inhibit CYP3A (IC50: 1.1 and 4.6 μM). In cultures of uninfected human PBMCs, Ritonavir significantly reduced the susceptibility of PBMCs to apoptosis (associated with low levels of caspase-1 expression), decreased caspase-3 activity, and reduced membrane-bound protein staining. Ritonavir inhibited the induction of tumor necrosis factor produced by PBMCs and monocytes at nontoxic concentrations in a time- and dose-dependent manner.

Storage & Handling

• Storage: store at low temperature,keep away from moisture | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

ABT538, ABT-538, ABT 538, Abbott 84538, A 84538, A84538, A-84538, Apoptosis, HIVProtease, HIV Protease, HIV, Human immunodeficiency virus, Inhibitor, inhibit, Ritonavir, RTV, SARS-CoV, SARSCoV, SARS coronavirus

Compound Identifiers

PubChem CID

392622