Ripretinib

SKU: orb1298897

Description

Ripretinib (DCC-2618) is a small molecule research compound designed as an orally administered inhibitor targeting KIT and PDGFRA kinases. It is utilized in preclinical studies, including in vitro assays and in vivo models, for investigating gastrointestinal stromal tumors (GIST) and related oncogenic signaling pathways.

Research Area

Cardiovascular Research, Cell Biology, Signal Transduction

Key Properties

• CAS Number: 1442472-39-0
• MW: 510.36
• Purity: 99.72%
• Formula: C₂₄H₂₁BrFN₅O₂
• SMILES: CCn1c2cc(NC)ncc2cc(-c2cc(NC(=O)Nc3ccccc3)c(F)cc2Br)c1=O
• Target: PDGFR,Apoptosis,c-Kit,VEGFR,FLT
• Solubility: DMSO:41.67 mg/mL (81.65 mM);10% DMSO+90% Corn Oil:2 mg/mL (3.92 mM)

Storage & Handling

• Storage: store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

Apoptosis, CD117, CD135, c-Kit, cKit, Cluster of differentiation antigen 135, Platelet-derived growth factor receptor, Kit, inhibit, Inhibitor, Fms like tyrosine kinase 3, DCC-2618, DCC2618, DCC 2618, FLT3, SCFR, Ripretinib, PDGFR, Vascular endothelial growth factor receptor, VEGFR

Compound Identifiers

PubChem CID

71584930