RIPK2-IN-8

SKU: orb3135943

Description

RIPK2-IN-8 is an orally active and highly selective RIPK2 inhibitor with an IC50 of 11 nM. It exhibits greater selectivity for RIPK2 over RIPK1 (IC50 > 30,000 nM) and has moderate inhibitory effects on RIPK3 (IC50 = 44.61 nM). RIPK2-IN-8 exerts anti-inflammatory effects by inhibiting the NOD2-RIPK2 signaling pathway and the expression of inflammatory cytokines IL-6 and TNFα. Additionally, in models of acute liver injury (ALI), RIPK2-IN-8 demonstrates both anti-inflammatory and hepatoprotective effects, making it useful for ALI research.

Research Area

Cell Biology, Immunology & Inflammation, Signal Transduction

Key Properties

• CAS Number: 3036254-29-9
• MW: 453.56
• Formula: C₂₂H₂₀FN₅OS₂
• SMILES: O=C(NC1CC=C(C=2SC3=C(N=CN=C3NC4=CC=5N=CSC5C=C4F)C2)CC1)CC
• Target: NF-κB,Interleukin,p38 MAPK,RIP kinase

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Quick Database Links

Gene Symbol

NF-κB,Interleukin,p38 MAPK,RIP kinase