RIPK1-IN-4

SKU: orb1708668

Description

RIPK1-IN-4 is a potent and selective type II inhibitor that targets the inactive DLG-out conformation of RIP1 kinase, exhibiting IC50 values of 16 nM and 10 nM in respective assays. This compound is a valuable research tool for investigating necroptosis and inflammatory pathways in both cellular and animal models of disease.

Research Area

Cell Biology, Signal Transduction

Key Properties

• CAS Number: 1481641-08-0
• MW: 401.46
• Purity: 99.94% (May vary between batches)
• Formula: C₂₃H₂₃N₅O₂
• SMILES: CC(C)(C)c1cc(NC(=O)Nc2ccc(cc2)-c2cccc3c(N)nccc23)no1
• Target: RIP kinase
• Solubility: 10% DMSO+40% PEG300+5% Tween 80+45% Saline:5 mg/mL (12.45 mM);DMSO:225 mg/mL (560.45 mM)

Bioactivity

• Target IC50:
  ADP-Glo:10 nM |RIP1:16 nM

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

ADP-Glo, RIPkinase, RIPK1 IN 4, RIPK1IN4, RIPK-1-IN-4, RIPK1-IN-4, RIP1, RIP kinase

Compound Identifiers

PubChem CID

71816195