RIPK1-IN-39

SKU: orb3174954

Description

RIPK1-IN-39 (compound 2) is a potent and selective inhibitor of RIPK1 with an IC50 of 69.40 nM, exhibiting over 100-fold selectivity for RIPK1 over RIPK3 (IC50= 6946 nM). It protects HT-22 and HT-29 cells from necroptosis by inhibiting the phosphorylation and activation of the RIPK1-RIPK3-MLKL pathway. Additionally, RIPK1-IN-39 shows neuroprotective effects in a rat middle cerebral artery occlusion (MCAO) model. This compound is applicable in acute ischemic stroke (AIS) research.

Key Properties

• CAS Number: 3065634-42-3
• MW: 525.6
• Formula: C₂₉H₂₄FN₅O₂S
• SMILES: C(N[C@@H](C)C1=CC=C(F)C=C1)(=O)C=2C3=C(C=CC(=C3)C=4C=C5C(=CC4)N=C(NC(=O)C6CC6)S5)N=C(C)N2
• Target: Apoptosis,RIP kinase

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Quick Database Links

Gene Symbol

Apoptosis,RIP kinase