RIPK1-IN-34

SKU: orb3173773

Description

RIPK1-IN-34 is a selective RIPK1 inhibitor capable of penetrating the blood-brain barrier with an IC50 of 126.70 nM, showing minimal inhibition of RIPK3 (IC50 > 10,000 nM). It exerts significant neuroprotective effects by inhibiting the phosphorylation of RIPK1, RIPK3, and mixed lineage kinase domain-like pseudokinase (MLKL) in the necroptosis pathway. RIPK1-IN-34 demonstrates neuroprotective effects in rat models of middle cerebral artery occlusion (MCAO) and is a candidate for research in the treatment of acute ischemic stroke (AIS).

Key Properties

• CAS Number: 3065634-19-4
• MW: 491.56
• Formula: C₂₈H₂₅N₇O₂
• SMILES: C(N[C@@H](C)C1=CC=CC=C1)(=O)C=2C3=C(C=CC(=C3)C4=CC=5N(C=C4)N=C(NC(=O)C6CC6)N5)N=C(C)N2
• Target: MLK,Necroptosis,RIP kinase

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Quick Database Links

Gene Symbol

MLK,Necroptosis,RIP kinase