RIPK1-IN-17

SKU: orb1943496

Description

RIPK1-IN-17 is a dual RIPK1/RIPK3 inhibitor that blocks necroptosis by preventing the phosphorylation of RIPK1, RIPK3, and MLKL. It has demonstrated in vivo efficacy by protecting mice from TNF-induced systemic inflammatory response syndrome (SIRS), hypothermia, and lethality, making it a valuable research tool for studying necroptosis in inflammatory disease models.

Research Area

Cell Biology, Signal Transduction

Key Properties

• CAS Number: 3033385-59-7
• MW: 529.51
• Purity: 95.22%
• Formula: C₂₆H₁₉F₄N₃O₃S
• SMILES: FC1=C(NC(CC2=CC=CC(OC(F)(F)F)=C2)=O)C=C(C3=CC=C(N=C(NC(C4CC4)=O)S5)C5=C3)C=C1
• Target: RIP kinase
• Solubility: DMSO:40 mg/mL (75.54 mM)

Storage & Handling

• Storage: Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

RIP kinase, RIPkinase

Compound Identifiers

PubChem CID

169450389