RIPK1-IN-16

SKU: orb1943495

Description

RIPK1-IN-16 is a potent, orally bioavailable small molecule inhibitor of RIPK1. It blocks RIPK1-mediated necroptosis, providing protection in murine models of TNF-driven systemic inflammatory response syndrome (SIRS) and sepsis, making it a valuable tool for studying inflammatory and cell death pathways in vivo and in vitro.

Research Area

Cell Biology, Signal Transduction

Key Properties

• CAS Number: 2561431-77-2
• MW: 393.46
• Formula: C₂₀H₁₉N₅O₂S
• SMILES: CN1C=2C(OC[C@H](NC(=O)C=3NC(CC4=CC=CC=C4)=NN3)C1=S)=CC=CC2
• Target: RIP kinase

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Compound Identifiers

PubChem CID

155357328