RIPGBM

SKU: orb1307795

Description

RIPGBM is a small molecule that selectively induces apoptosis in glioblastoma multiforme (GBM) cancer stem cells with an EC50 of ≤500 nM. It is a valuable research tool for studying GBM stem cell biology and has demonstrated efficacy in both in vitro and in vivo experimental models.

Research Area

Cell Biology

Key Properties

• CAS Number: 355406-76-7
• MW: 428.45
• Purity: 99.86%
• Formula: C₂₆H₂₁FN₂O₃
• SMILES: CC(=O)N(CC1=CC=C(F)C=C1)C1=C(NCC2=CC=CC=C2)C(=O)C2=C(C=CC=C2)C1=O
• Target: Apoptosis
• Solubility: 10% DMSO+40% PEG300+5% Tween 80+45% Saline:2 mg/mL (4.67 mM);DMSO:30 mg/mL (70.02 mM)

Bioactivity

• Target IC50:
  Apoptosis (GBM CSCs):(EC50)≤500 nM
• In Vitro:
  RIPGBM causes caspase 1-dependent apoptosis by binding to receptor-interacting protein kinase 2 and acting as a molecular switch. It reduces the formation of a prosurvival RIPK2/ TAK1 complex and increases the formation of a proapoptotic RIPK2/caspase 1 complex .

Storage & Handling

• Storage: Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

RIPGBM, Inhibitor, inhibit, Apoptosis inducer, Apoptosis, in GBM CSCs, Apoptosis

Compound Identifiers

PubChem CID

3793001