RIPA-56

SKU: orb1299499

Description

RIPA-56

Research Area

Cell Biology, Signal Transduction

Key Properties

• CAS Number: 1956370-21-0
• MW: 221.3
• Purity: 100.00%
• Formula: C₁₃H₁₉NO₂
• SMILES: CCC(C)(C)C(=O)N(O)Cc1ccccc1
• Target: RIP kinase
• Solubility: DMSO:100 mg/mL (451.88 mM);10% DMSO+40% PEG300+5% Tween 80+45% Saline:4 mg/mL (18.08 mM)

Bioactivity

• Target IC50:
  RIP1:13 nM
• In Vivo:
  In the SIRS mice disease model, RIPA-56 efficiently reduced tumor necrosis factor alpha (TNFα)-induced mortality and multi-organ damage. Compared to known RIP1 inhibitors, RIPA-56 is potent in both human and murine cells, is much more stable in vivo, and is efficacious in animal model studies.

Storage & Handling

• Storage: Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

Inhibitor, inhibit, RIP kinase, RIPkinase, RIP1, RIPA 56, RIPA56, RIPA-56, RIPK, Receptor-interacting protein kinases

Compound Identifiers

PubChem CID

121439991