Rilmenidine Phosphate

SKU: orb1221725

Description

Rilmenidine Phosphate is a selective I(1) imidazoline receptor agonist, used to treat hypertension.(In Vitro):Rilmenidine provides antihypertensive efficacy comparable with that of diuretics, beta-blockers, calcium channel blockers, and angiotensin-converting enzyme (ACE) inhibitors.Rilmenidine phosphate (25-100 μM; 24 hours) inhibits K562 cell proliferation.(In Vivo):Rilmenidine phosphate-treated N171-82Q mice (i.p.; 4-times a week) displays significant improved forelimb grip strength and all limbs grip strength from 12 to 22 weeks of age.Rilmenidine phosphate decreases levels of mutant huntingtin.

Key Properties

• CAS Number: 85409-38-7
• MW: 278.24
• Purity: >98% (HPLC)
• Formula: C₁₀H₁₉N₂O₅P
• SMILES: C1CC1C(C1CC1)NC1=NCCO1.OP(=O)(O)O
• Target: I(1) imidazoline receptor
• Solubility: In Vitro: H2O : 83.33 mg/mL (299.49 mM)

Bioactivity

• In Vivo:
  Rilmenidine phosphate-treated N171-82Q mice (i.p.; 4-times a week) displays significant improved forelimb grip strength and all limbs grip strength from 12 to 22 weeks of age. Rilmenidine phosphate decreases levels of mutant huntingtin.
• In Vitro:
  Rilmenidine provides antihypertensive efficacy comparable with that of diuretics, beta-blockers, calcium channel blockers, and angiotensin-converting enzyme (ACE) inhibitors. Rilmenidine phosphate (25-100 μM; 24 hours) inhibits K562 cell proliferation. Cell Proliferation Assay Cell line: K562 cells. Concentration: 25, 50, 100 μM. Incubation time: 24 hours. Result: Dose-dependently inhibited K562 colony formation.

Storage & Handling

• Storage: Storage temperature: -20°C. Stability: ≥ 2 years
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Quick Database Links

Gene Symbol

I(1) imidazoline receptor