RIG012

SKU: orb1744128

Description

RIG012 is a potent small molecule inhibitor of the RIG-I receptor, exhibiting an IC50 of 0.71 μM in an ATPase activity assay. It effectively suppresses downstream antiviral signaling, including the expression of IFN-β and ISGs like hRsad2, making it a valuable tool for studying innate immune pathways in vitro.

Research Area

Immunology & Inflammation

Key Properties

• CAS Number: 2642218-43-5
• MW: 359.42
• Purity: 99.53% (May vary between batches)
• Formula: C₂₃H₂₁NO₃
• SMILES: C(C)C1(CC)C=2C(C=3C(C(=O)C2OCC4=CC=CC=C4)=CC=CC3)=NC1=O
• Target: IFNAR,Others
• Solubility: DMSO:36.43 mg/mL (101.36 mM)

Bioactivity

• Target IC50:
  RIG-I:0.71 μM
• In Vitro:
  RIG012 (1, 1.25, 1.5, 2, 2.5, 3, 4 μM) has potent dose-dependent inhibition of RIG-I signaling in HEK293T cells co-transfected with expression plasmids and reporter plasmids. RIG012 (1.25, 2.25, 4.5, 9, 18 μM) has potent dose-dependent inhibition of IFN-β and ISG hRsad2 expression in A549 cells. RIG012 contains a strong chromophore that absorbs in the visible range (λmax of 470 nm). Upon binding to RIG-I, the 470 nm absorption band of RIG012 undergoes a significant hyperchromic shift toward higher intensity values.
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Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

RIG-I

Compound Identifiers

PubChem CID

154717119