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With the rapid growth of global demand for biomedicine, traditional protein production technologies are confronted with challenges such as high costs, difficulty in scaling up, and numerous safety hazards. In this article, we’d like to introduce to you an innovative and green protein expression platform- Rice Endosperm Cell Specific Expression Platform.
This specific expression platform uses "rice endosperm cells" as bioreactors to highly and specifically express various recombinant proteins and short peptides.
- High Expression Level: By utilizing endosperm cell-specific promoters, protein directed storage, and gene codon optimization technology, this platform enables recombinant protein expression in rice seeds to reach 20–150 μg per grain, which is a 10- to 1000-fold increase in yield compared to other expression systems, and the yield of recombinant protein is increased from mg level to 20g level.
- High Biological Activity: In rice endosperm, recombinant proteins are accurately folded and modified by the plant's eukaryotic machinery and stored in Rice Protein Bodies, thereby maximizing protein stability and bioactivity.
- High Economic Benefits: By expanding the scale of rice cultivation, purified recombinant proteins or peptides can reach the kilogram level within two years.
- Chemical Definition: Being free of animal-derived pathogens, this platform eliminates or significantly reduces potential risks from viruses and other unknown factors associated with blood-derived products.
- Environmental Protection: The Rice Endosperm Cell Specific Expression Platform does not release CO2 or sewage.
Recombinant Human Transferrin | Recombinant Human Alpha-1 Antitrypsin |
Recombinant Human Lactoferrin | Recombinant Human Lysozyme |
Recombinant Human Keratinocyte Growth Factor | Recombinant Human Vascular Endothedial Growth Factor |
- In the purity analyses of SDS-PAGE and SEC-HPLC, the purity of Recombinant Human Fibronectin exceeded 95%.
- Morphological and IF staining analyses demonstrated that Recombinant Human Fibronectin can effectively maintain the activity of neuronal cells.
- In Biopharmaceutical Field: They can be used for cell culture and vaccine production as a serum-free medium additive, supporting the efficient preparation of stem cells, monoclonal antibodies, and vaccines.
- Industrial and Scientific Research Reagents: Some proteases and growth factors, such as recombinant human lysozyme and fibroblast growth factor (FGF), are widely used in the development of biopharmaceutical intermediates and in vitro diagnostic reagents.
- Beauty & Health Products: Bioactive ingredients such as lactoferrin and anti-aging factors, combining both safety and efficacy, are utilized as high-performance actives in premium skincare formulations.
