RHPS4

SKU: orb1300304

Description

RHPS4 methosulfate is a submicromolar-potency telomerase inhibitor. It is a research tool used in vitro and in vivo to study telomere biology, cellular senescence, and oncology, particularly in the context of cancer therapeutics.

Research Area

Cell Biology, Molecular Biology

Key Properties

• CAS Number: 390362-78-4
• MW: 458.48
• Purity: 99.72% (May vary between batches)
• Formula: C₂₂H₁₇F₂N₂·CH₃O₄S
• SMILES: COS([O-])(=O)=O.Cc1cc2n(C)c3ccc(F)cc3c3[n+](C)c4ccc(F)cc4c(c1)c23
• Target: Apoptosis,Telomerase
• Solubility: H2O:< 1 mg/mL (insoluble or slightly soluble);DMSO:4.9 mg/mL (10.69 mM);Ethanol:< 1 mg/mL (insoluble or slightly soluble)

Bioactivity

• Target IC50:
  Telomerase:0.33 μM (IC50)
• In Vitro:
  CP 673451 is a selective inhibitor of PDGFRα/β with IC50 of 10 nM/1 nM, exhibits >450-fold selectivity over other angiogenic receptors. In glioblastoma tumors, CP-673451 (33 mg/kg) provides >50% inhibition of PDGFR-β receptor for 4 hours corresponding to an EC50 of 120 ng/mL in plasma at Cmax. In a sponge angiogenesis model, CP-673451 inhibits 70% of PDGF-BB-stimulated angiogenesis at a dose of 3 mg/kg (q.d. ×5, p.o., corresponding to 5.5 ng/mL at Cmax). CP-673451 decreases cell proliferation rate through mechanisms involving reduced phosphorylation of GSK-3α and GSK-3β. In both RD and RUCH2 cultures, CP-673451 impairs rhabdosphere-forming capacity and cell differentiation, causes increased senescence.

Storage & Handling

• Storage: Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

RHPS 4, RHPS4, RHPS-4, Telomerase, CG5, Apoptosis, NSC714187, NSC-714187, NSC 714187, M14, PC3, HT29, H2AX, H460

Compound Identifiers

PubChem CID

9804187