Rhosin hydrochloride

SKU: orb1307799

Description

Rhosin hydrochloride

Research Area

Cell Biology, Pharmacology & Drug Discovery, Signal Transduction

Key Properties

• CAS Number: 1281870-42-5
• MW: 431.318
• Purity: 97.33%
• Formula: C₂₀H₂₀Cl₂N₆O
• SMILES: Cl.N[C@H](Cc1c[nH]c2ccccc12)C(=O)N\N=C\c1ccc2nccnc2c1
• Target: Apoptosis,Rho,Ras
• Solubility: DMSO:49 mg/mL (113.61 mM);10% DMSO+40% PEG300+5% Tween 80+45% Saline:4 mg/mL (9.27 mM)

Bioactivity

• Target IC50:
  RhoA:(kd)0.4 uM
• In Vivo:
  METHODS: B16BL6 cells and 4T1 cells were injected into the tail vein of syngeneic C57BL/6J mice and Balb/c mice. Mice were treated with 10 or 30 mg/kg of Rhosin hydrochloride daily from day 1 to day 14. RESULTS The number of lung metastatic nodules in B16BL6 and 4T1 cells was reduced in a dose-dependent manner after administration of Rhosin hydrochloride, and Rhosin hydrochloride inhibited the metastasis of 4T1-luc tumor cells to the lung region, which could be confirmed by the reduction of photon flux.
• In Vitro:
  METHODS: To investigate the cytotoxic effects of Rhosin hydrochloride on B16BL6 and 4T1 cells, cell viability was assessed by treating cells with 1-100 μM Rhosin hydrochloride. RESULTS Rhosin hydrochloride at a concentration of 100 μM induced cell death in B16BL6 and 4T1 cells.

Storage & Handling

• Storage: store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

D1-MSN, cells, Apoptosis, MCF7, hyperexcitability, Inhibitor, inhibit, Rhosin, Rhosin hydrochloride, Rhosin Hydrochloride, RhoA, resiliency, plasticity, stress, selective, Ras

Compound Identifiers

PubChem CID

52998412