Rho-Kinase-IN-1

SKU: orb1708680

Description

Rho-Kinase-IN-1 is a potent and selective ROCK inhibitor, exhibiting Kis of 30.5 nM for ROCK1 and 3.9 nM for ROCK2. This small molecule is a valuable research tool for investigating pathological processes involving excessive proliferation, tissue remodeling, and inflammation in both cellular and animal models.

Research Area

Cell Biology, Signal Transduction, Stem Cell & Developmental Biology

Key Properties

• CAS Number: 1035094-83-7
• MW: 352.5
• Purity: 99.80% (May vary between batches)
• Formula: C₂₀H₂₄N₄S
• SMILES: CSc1ccc(CN2CCCC(C2)Nc2ccc3[nH]ncc3c2)cc1
• Target: ROCK
• Solubility: 10% DMSO+40% PEG300+5% Tween 80+45% Saline:2 mg/mL (5.67 mM);DMSO:65 mg/mL (184.4 mM)

Bioactivity

• Target IC50:
  ROCK1:30.5 nM (ki)|ROCK2:3.9 nM (ki)

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

Rho Kinase IN 1, RhoKinaseIN1, Rho-Kinase-IN-1, ROCK1, ROCK2

Compound Identifiers

PubChem CID

25008330