Rhein

SKU: orb1304757

Description

Rhein (NSC 38629) is a bioactive anthraquinone isolated from Rheum officinale, exhibiting anti-inflammatory and antitumor properties. It is utilized in research to study mechanisms of apoptosis and cell cycle arrest in various cancer cell lines, as well as in animal models of inflammation and tumorigenesis.

Research Area

Cell Biology, Immunology & Inflammation, Infectious Disease & Virology, Metabolism Research, Signal Transduction

Key Properties

• CAS Number: 478-43-3
• MW: 284.22
• Purity: 99.04%
• Formula: C₁₅H₈O₆
• SMILES: OC(=O)C1=CC2=C(C(O)=C1)C(=O)C1=C(C=CC=C1O)C2=O
• Target: Apoptosis,Autophagy,ROS,Antibacterial,Reactive Oxygen Species
• Solubility: DMSO:5.45 mg/mL (19.18 mM)

Bioactivity

• In Vivo:
  In chondrocytes, Rhein (35 µM) effectively inhibits the synthesis of IL-1β in human osteoarthritis synovium and exerts effects in cartilage by reducing the amount of IL-1R and inhibiting the production of NO induced by IL-1β. Additionally, Rhein is capable of inducing apoptosis in acute promyelocytic leukemia cells (HL-60).
• In Vitro:
  In diabetic nephropathy-afflicted db/db mice, Rhein effectively ameliorates diabetic renal lesions and mitigates hyperlipidemia by reducing plasma cholesterol (Chol), triglycerides (TG), low-density lipoprotein cholesterol (LDL-C), ApoE, and renal tissue transforming growth factor-β1 (TGF-β1).

Storage & Handling

• Storage: Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

Monorhein, NSC 38629, NSC38629, NSC-38629, Bacterial, Autophagy, Reactive Oxygen Species, ReactiveOxygenSpecies, Rheic Acid, Rhein, Rheinic Acid, Rhubarb yellow

Compound Identifiers

PubChem CID

10168