RHC-80267 (U-57908)

SKU: orb1299098

Description

RHC 80267 (U-57908) is a selective diacylglycerol lipase (DAGL) inhibitor with an IC50 of 4 µM in canine platelets. This compound is a valuable research tool for studying endocannabinoid biosynthesis and 2-AG signaling pathways in both cellular and in vivo models of neurological and metabolic research.

Research Area

Immunology & Inflammation, Metabolism Research, Neuroscience

Key Properties

• CAS Number: 83654-05-1
• MW: 394.5
• Purity: >98%
• Formula: C₂₀H₃₄N₄O₄
• SMILES: O=C(NCCCCCCNC(=O)ON=C1CCCCC1)ON=C1CCCCC1
• Target: Lipase
• Solubility: Soluble in DMSO (up to 25 mg/ml) or in Ethanol (up to 25 mg/ml).

Bioactivity

• Target IC50:
  DAGL:4 µM in canine platelets
• In Vitro:
  RHC-80267 is thought to initiate activation of protein kinase C.2 At 0.3-1 μM, it has been reported to enhance acetylcholine-induced smooth muscle relaxation in vitro

Storage & Handling

• Storage: RT
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

U-57908

Compound Identifiers

PubChem CID

5063