RGX-202

SKU: orb1299731

Description

RGX-202

Research Area

Cell Biology, Epigenetics & Chromatin, Metabolism Research, Molecular Biology, Signal Transduction

Key Properties

• CAS Number: 353-09-3
• MW: 131.13
• Purity: 98.00% (May vary between batches)
• Formula: C₄H₉N₃O₂
• SMILES: C(CC(O)=O)NC(=N)N
• Target: AMPK,Apoptosis,Endogenous Metabolite,PPAR
• Solubility: H2O:50 mg/mL (381.3 mM);DMSO:Slightly soluble

Bioactivity

• In Vivo:
  3-Guanidinopropionic Acid(β-GPA) downregulated the expression of the β-oxidation genes. Administration of β-GPA in mice for 3 weeks improved the animals' physical strength and endurance health, ie, increased their physical strength and endurance and alleviated anxiety. β-GPA might be considered an adaptogene affecting both the muscle and brain metabolism in mammals.
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• In Vitro:
  3-Guanidinopropionic acid evokes a shift from glycolytic to oxidative metabolism, increased cellular glucose uptake, and increased fatigue tolerance
• Animal Research:
  The following animal groups were used for the experiment: (1) mice that were not subjected to injections (n = 10)—this group was used only for physiological tests and were not killed after the experiment; (2) saline-treated mice (n = 8)—the volume of injections was 200 μL; and (3) β-GPA-treated mice (n = 8)—concentration of β-GPA was 1 mg/kg/day. The volume of injections was 200 μL.Injections were performed 3 times a week for 3 weeks. The mice's weight and the total amount of consumed food and water were measured daily. Once a week, a string test was performed. Measurements of the oxygen consumption rates of live animals and the open field test were performed after the course of injections. After 3 weeks, the mice were killed; brain dissection was performed to extract the cortex and the ventral midbrain (VMB) for quantitative real-time polymerase chain reaction (qRT-PCR) analysis.
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Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

creatine import, beta-GPA, 3-Guanidinopropionic Acid, apoptosis, AMPK, cancer, b-GPA, oral, mice, inhibit, Inhibitor, Endogenous Metabolite, PPARγ, RGX 202, RGX202, RGX-202, β-GPA

Compound Identifiers

PubChem CID

67701