RGB-286638 free base

SKU: orb1305572

Description

RGB-286638 free base is a potent and selective cyclin-dependent kinase (CDK) inhibitor, exhibiting single-digit nM IC50 values against CDK1, CDK2, CDK3, CDK4, CDK5, and CDK9, with reduced activity against CDK6 and CDK7. This tool compound is used in biochemical and cellular research to investigate CDK function in cell cycle progression, transcription, and associated diseases.

Research Area

Cardiovascular Research, Cell Biology, Epigenetics & Chromatin, Signal Transduction, Stem Cell & Developmental Biology

Key Properties

• CAS Number: 784210-88-4
• MW: 545.63
• Purity: 99.91% (May vary between batches)
• Formula: C₂₉H₃₅N₇O₄
• SMILES: COCCN1CCN(Cc2ccc(cc2)-c2n[nH]c3-c4cccc(NC(=O)NN5CCOCC5)c4C(=O)c23)CC1
• Target: JAK,GSK-3,MEK,CDK
• Solubility: 0.1M HCl:1 mg/mL (1.83 mM);15% Solutol HS-15 in Saline:10 mg/mL (18.33 mM);DMSO:Slightly soluble

Bioactivity

• Target IC50:
  Cyclin D1-CDK4:4 nM|Cyclin E-CDK2:3 nM|CDK7-CyclinH:44 nM|MEK1:54 nM|AMPK:41 nM|Cyclin B1-CDK1:2 nM|JNK1a2:40 nM|GSK-3β:3 nM|CDK5-p35:5 nM|JNK1a1:17 nM|JAK2:50 nM|Cyclin T1-CDK9:1 nM|CDK6-CyclinD3:55 nM|TAK1:5 nM|c-Src:25 nM|Cyclin E-CDK3:5 nM

Storage & Handling

• Storage: Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

Cyclin dependent kinase, CDK2/cyclinE, CDK3/cyclinE, CDK4/cyclinD1, CDK9/cyclin T1, CDK1/cyclinB1, CDK, Janus kinase, JAK, inhibit, Mitogen-activated protein kinase kinase, MAP2K, MAPKK, MEK, Inhibitor, Glycogen synthase kinase 3, Glycogen synthase kinase-3, GSK3, GSK-3, p35-CDK5, RGB 286638, RGB 286638 free base, RGB286638, RGB-286638, RGB286638 free base, RGB-286638 free base

Compound Identifiers

PubChem CID

11285002