RG33

• Catalog Number: orb1140616
• Category: Proteins
• Description: Apolipoprotein A1 (ApoA-I) mimetic, improves glucose clearance and control; Peptides.
• Modifications: N terminal acetyl, C terminal amide.
• Structure: Ac-Pro-Ala-Leu-Glu-Asp-Leu-Arg-Gln-Gly-Leu-Leu-Pro-Val-Leu-Glu-Ser-Phe-Lys-Val-Ser-Phe-Leu-Ser-Ala-Leu-Glu-Glu-Tyr-Thr-Lys-Lys-Leu-Asn-NH2
• Target Areas: Protein-protein interactions
• Form/Appearance: Freeze dried solid
• Purity: > 95% by HPLC
• MW: 3790.41 Da
• Formula: C₁₇₅H₂₈₂N₄₂O₅₁
• Solubility (25°C): > 3 mg/ml in water
• Protein Sequence: Ac-Pro-Ala-Leu-Glu-Asp-Leu-Arg-Gln-Gly-Leu-Leu-Pro-Val-Leu-Glu-Ser-Phe-Lys-Val-Ser-Phe-Leu-Ser-Ala-Leu-Glu-Glu-Tyr-Thr-Lys-Lys-Leu-Asn-NH2
• Storage: Store desiccated, frozen and in the dark
• Alternative names: Ac-PALEDLRQGLLPVLESFKVSFLSALEEYTKKLN-NH2, ApoA-IGH
• Background: RG33 is a peptide corresponding to the two last helical segments, amino acid residues 209-241 of apolipoprotein A1 (ApoA-I), the major protein component of high-density lipoprotein (HDL) particles in plasma. ApoA-I has a specific role in lipid metabolism and enables efflux of molecules by accepting fats from within cells for transport and metabolism elsewhere. In vivo RG33 peptide efficiently solubilizes lipid vesicles, and promotes the efflux of cholesterol from cultured macrophages. In vitro RG33 peptide significantly improves the glucose clearance capacity of insulin resistant mice and provides systemic glucose control in an insulin resistant mouse model.
• Note: For research use only
• Expiration Date: 12 months from date of receipt.