RG108

SKU: orb1306670

Description

RG108 (N-Phthalyl-L-tryptophan) is a potent and cell-permeable inhibitor of DNA methyltransferases with an IC50 of 115 nM. It is widely used in epigenetic research to reactivate silenced genes and has been applied in both cellular and animal studies to investigate DNA methylation's role in development and disease.

Research Area

Epigenetics & Chromatin

Key Properties

• CAS Number: 48208-26-0
• MW: 334.33
• Purity: 99.78% (May vary between batches)
• Formula: C₁₉H₁₄N₂O₄
• SMILES: [C@H](CC=1C=2C(NC1)=CC=CC2)(C(O)=O)N3C(=O)C=4C(C3=O)=CC=CC4
• Target: DNA Methyltransferase
• Solubility: DMSO:255 mg/mL (762.72 mM);Ethanol:33.4 mg/mL (99.9 mM);10% DMSO+40% PEG300+5% Tween 80+45% Saline:2 mg/mL (5.98 mM)

Bioactivity

• Target IC50:
  DNA methyltransferase:115 nM
• In Vivo:
  In iPS cells derived from SM, RG108 significantly reduces DNA activity. In tumor cells, RG108 inhibits gene demethylation and reactivation without affecting the methylation of telomeric gene sequences.
• Cell Research:
  For the determination of cellular growth and viability, cells are stained with trypan blue and counted using a standard counting grid.(Only for Reference)

Storage & Handling

• Storage: Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

DNA Methyltransferase, DNA methyltransferase (DNMT), DNA MTases, DNAMethyltransferase, DNMTs, N-Phthalyl-L-tryptophan, inhibit, Inhibitor, RG108, RG-108, RG 108

Compound Identifiers

PubChem CID

702558