REVERSE T3

SKU: orb1299690

Description

This small molecule is a thyroid hormone analog that antagonizes the sodium current-enhancing effects of other thyronamines in neonatal rat cardiomyocytes. It is a key tool for investigating cardiac electrophysiology and thyroid hormone signaling in both in vitro and in vivo models.

Research Area

Metabolism Research

Key Properties

• CAS Number: 5817-39-0
• MW: 650.97
• Purity: 98.89% (May vary between batches)
• Formula: C₁₅H₁₂I₃NO₄
• SMILES: N[C@@H](CC1=CC(I)=C(OC2=CC(I)=C(O)C(I)=C2)C=C1)C(O)=O
• Target: Thyroid hormone receptor(THR)
• Solubility: DMSO:17.76 mg/mL (27.28 mM)

Bioactivity

• In Vitro:
  Reverse T3(T3) pre-conditioning leads to beneficial effects in the liver of brain-dead rats as seen by lower cellular injury and reduced apoptosis, and supports the suggested role of reverse T3(T3) hormone therapy in the management of brain-dead donors.
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• Cell Research:
  Brain death (BD) was induced in mechanically ventilated rats by inflation of a Fogarty catheter in the epidural space. T3 (0.1 mg/kg) or vehicle was administered intraperitoneally 2 h prior to BD induction. After 4 h of BD, serum and liver tissue were collected. RT-qPCR, routine biochemistry, and immunohistochemistry were performed.
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Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

Thyroid hormone receptor, Thyroid hormone, Thyroid Hormone Receptor, Thyroid hormone receptor(THR), Thyroidhormonereceptor(THR), Thyroidhormonereceptor, THR, Reverse T 3, REVERSE T3, REVERSE T-3, inhibit, Inhibitor, 3′,5′,3-Triiodothyronine, 3,3',5'-triiodo-L-thyronine

Compound Identifiers

PubChem CID

644280