RET-IN-3

SKU: orb1685243

Description

RET-IN-3 is a selective kinase inhibitor targeting the RET V804M gatekeeper mutation. It is a research tool for investigating RET-driven oncogenesis, with utility in both in vitro biochemical assays and in vivo models of non-small cell lung cancer (NSCLC).

Research Area

Cell Biology, Signal Transduction

Key Properties

• CAS Number: 2414374-53-9
• MW: 339.39
• Purity: 99.83% (May vary between batches)
• Formula: C₁₈H₂₁N₅O₂
• SMILES: CN(C)CCCNc1ccn2ncc(-c3ccc4OCOc4c3)c2n1
• Target: c-RET
• Solubility: 10% DMSO+40% PEG300+5% Tween 80+45% Saline:2 mg/mL (5.89 mM);DMSO:50 mg/mL (147.32 mM)

Bioactivity

• Target IC50:
  RET (V804M):19 nM
• In Vitro:
  In comparison to wt-RET and KDR, RET-IN-3 demonstrates selectivity with folds of 16 and 410, respectively..

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

cRET, RET IN 3, RETIN3, RET-IN-3, RETV804M

Compound Identifiers

PubChem CID

146018674