RET-IN-14

SKU: orb1686575

Description

RET-IN-14 is a potent small molecule inhibitor targeting RET wild-type and gatekeeper mutants (V804M, G810R), as well as BTK (C481S), with IC50 values in the low nanomolar range. It is a valuable research tool for investigating RET-driven and BTK-related oncogenesis in both cellular and animal models of cancer.

Research Area

Cardiovascular Research, Cell Biology, Signal Transduction

Key Properties

• CAS Number: 2755843-62-8
• MW: 506.49
• Formula: C₂₄H₂₃FN₈O₄
• SMILES: NC=1N2C3=C(C=N2)C(=O)NC[C@H](C)OC=4C(CN=C(N3)C1C5=CC=C(NC(OC)=O)C=C5)=CC(F)=CN4
• Target: BTK,Others,c-RET

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Compound Identifiers

PubChem CID

163322181