RET-IN-1

SKU: orb1706727

Description

RET-IN-1 is a potent and selective small molecule inhibitor of the RET kinase, demonstrating nanomolar IC50 values against wild-type RET (1 nM) and its V804M (7 nM) and G810R (101 nM) mutants. It is a valuable chemical probe for investigating RET-driven oncogenesis in both cellular and animal models of cancers such as non-small cell lung cancer and medullary thyroid carcinoma.

Research Area

Cell Biology, Signal Transduction

Key Properties

• CAS Number: 2222755-14-6
• MW: 553.61
• Formula: C₂₉H₃₁N₉O₃
• SMILES: C(#N)C1=C2C(=CC(OC[C@H]3CNCCO3)=CN2N=C1)C=4C=NC(=CN4)N5CC6N(CC=7C=CC(OC)=NC7)C(C5)C6
• Target: c-RET,Others

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Compound Identifiers

PubChem CID

134437053