Relebactam

SKU: orb1226879

Description

Relebactam (MK-7655) is a novel β-lactamase inhibitor that inhibited both class A and C β-lactamases in vitro; effectively restored imipenem's activity against imipenem-resistant Pseudomonas and Klebsiella strains at clinically achievable concentrations; reduces imipenem MICs for Enterobacteriaceae with KPC carbapenemases from 16-64 mg/L to 0.12-1 mg/L at a concentration of 4 mg/L.Bacterial Infection Phase 3 Clinical(In Vitro):Relebactam combine with Imipenem demonstrates activity against KPC-producing Enterobacteriaceae and multidrug-resistant P. aeruginosa.Relebactam shows limited inhibition of Class D-producing bacteria and has antipseudomonal activity.

Research Area

Pharmacology & Drug Discovery

Key Properties

• CAS Number: 1174018-99-5
• MW: 348.3754
• Purity: >98% (HPLC)
• Formula: C₁₂H₂₀N₄O₆S
• SMILES: O=S(O)(ON1[C@]2([H])CC[C@@H](C(NC3CCNCC3)=O)[N@@](C2)C1=O)=O
• Target: Antibacterial
• Solubility: 10 mM in DMSO

Storage & Handling

• Storage: Storage temperature: -20°C. Stability: ≥ 2 years
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

MK-7655

Quick Database Links

Gene Symbol

Antibacterial