Regorafénib N-oxyde (M2)

SKU: orb1310045

Description

Regorafenib N-oxide M2 is the active metabolite of Regorafenib, a multi-kinase inhibitor targeting VEGFR, PDGFRβ, RET, Kit, and Raf-1. This compound is utilized in cancer research, particularly for studying drug metabolism and efficacy in both in vitro biochemical assays and in vivo tumor models.

Research Area

Cardiovascular Research, Cell Biology, Metabolism Research, Signal Transduction

Key Properties

• CAS Number: 835621-11-9
• MW: 498.81
• Purity: 99.48% (May vary between batches)
• Formula: C₂₁H₁₅ClF₄N₄O₄
• SMILES: CNC(=O)c1cc(Oc2ccc(NC(=O)Nc3ccc(Cl)c(c3)C(F)(F)F)c(F)c2)cc[n+]1[O-]
• Target: PDGFR,c-Kit,Drug Metabolite,c-RET,Raf,VEGFR
• Solubility: DMSO:5.67 mg/mL (11.37 mM)

Bioactivity

• Target IC50:
  PDGFRβ:1.5nM |c-Kit:7nM |Raf-1:2.5 nM |VEGFR1:13nM |VEGFR3:46nM |RET:22nM |VEGFR2:4.2nM

Storage & Handling

• Storage: Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

cKit, cRET, Drug Metabolite, DrugMetabolite, Inhibitor, Kit, inhibit, Platelet-derived growth factor receptor, PDGFR, VEGFR2, VEGFR1, VEGFR3, Regorafénib N-oxyde, Regorafénib Noxyde (M2), Regorafénib N-oxyde (M2), Regorafénib N-oxyde (M-2), Regorafénib N oxyde (M2), PDGFRβ, Raf-1, RET

Compound Identifiers

PubChem CID

53491674