Refametinib R enantiomer

SKU: orb1708694

Description

Refametinib (R enantiomer) is a potent and selective MEK inhibitor with an EC50 in the low nanomolar range. It is widely used in cancer research to investigate oncogenic signaling pathways and has demonstrated antitumor activity in both cellular and animal models of various cancers.

Research Area

Signal Transduction

Key Properties

• CAS Number: 923032-38-6
• MW: 572.34
• Purity: 99.86% (May vary between batches)
• Formula: C₁₉H₂₀F₃IN₂O₅S
• SMILES: S(NC1=C(NC2=C(F)C=C(I)C=C2)C(F)=C(F)C=C1OC)(=O)(=O)C3(C[C@H](CO)O)CC3
• Target: MEK
• Solubility: DMSO:55 mg/mL (96.1 mM)

Bioactivity

• Target IC50:
  MEK:2-15 nM （EC50）
• In Vitro:
  Refametinib R enantiomer is the R enantiomer of Refametinib. It functions as an MEK inhibitor and is used in the treatment of cancer and other hyperproliferative diseases.

Storage & Handling

• Storage: Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

BAY 869766 R enantiomer, MEK, RDEA119 R enantiomer, Refametinib R enantiomer

Compound Identifiers

PubChem CID

50912933