Recombinant Human Interleukin-1 Receptor Antagonist Protein

SKU: orb1906339

Description

Recombinant Human Interleukin-1 Receptor Antagonist Protein

Research Area

Immunology & Inflammation; Pharmacology & Drug Discovery

Key Properties

• Source: Escherichia coli
• Expression System: Escherichia coli
• Biological Activity: Fully biologically active when compared to standard. The ED50 as determined by inhibiting IL-1α-dependent proliferation of murine D10S cells is less than 40 ng/ml, corresponding to a specific activity of > 2.5 x104 IU/mg in the presence of 50 pg/ml rHuIL-1α.
• Molecular Weight: Approximately 17.1 kDa, a single non-glycosylated polypeptide chain containing 152 amino acids.
• Protein Sequence: RPSGRKSSKM QAFRIWDVNQ KTFYLRNNQL VAGYLQGPNV NLEEKIDVVP IEPHALFLGI HGGKMCLSCV KSGDETRLQL EAVNITDLSE NRKQDKRFAF IRSDSGPTTS FESAACPGWF LCTAMEADQP VSLTNMPDEG VMVTKFYFQE DE
• Purity: > 96 % by SDS-PAGE and HPLC analyses.
• Endotoxins: Less than 1 EU/ug of rHuIL-1RA as determined by LAL method.

Storage & Handling

• Storage: Use a manual defrost freezer and avoid repeated freeze-thaw cycles.- 12 months from date of receipt, -20 to -70 °C as supplied.- 1 month, 2 to 8 °C under sterile conditions after reconstitution.- 3 months, -20 to -70 °C under sterile conditions after reconstitution.
• Form/Appearance: Lyophilized from a 0.2 μm filtered concentrated solution in PBS, pH 7.4.
• Expiration Date: 6 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

IL-1RN, IRAP

Quick Database Links

UniProt

P18510