Reboxetine mesylate

SKU: orb1223479

Description

Reboxetine is a norepinephrine reuptake inhibitor with Ki of 8.2 nM.(In Vitro):Reboxetine mesylate has weak affinity for muscarinic, histaminergic H1, adrenergic α1, and dopaminergic D2 receptors.Reboxetine mesylate preventes the Dexamethasone-induced decreases in cell viability and proliferation rate.(In Vivo):Reboxetine mesylate (30 mg/kg; i.p.) significantly decreases the immobility time in the mice depression models.

Key Properties

• CAS Number: 98769-84-7
• MW: 409.5
• Purity: >98% (HPLC)
• Formula: C₁₉H₂₃NO₃·CH₄O₃S
• SMILES: CCOC1=CC=CC=C1OC(C2CNCCO2)C3=CC=CC=C3.CS(=O)(=O)O
• Target: Norepinephrine
• Solubility: Ethanol: <1 mg/mL\nDMSO: 82 mg/mL (200.24 mM)\nWater: 82 mg/mL (200.24 mM)

Bioactivity

• In Vivo:
  Reboxetine mesylate (30 mg/kg; i.p.) significantly decreases the immobility time in the mice depression models. Animal model: Harlan-bred, male CF-1 mice (18-20 g), depression models. Dosage: 3 mg/kg, 30 mg/kg. Administration: Intraperitoneal injection. Result: Significantly decreased the immobility time in the mouse tail suspension test at the dose of 30 mg/kg.
• In Vitro:
  Reboxetine mesylate has weak affinity for muscarinic, histaminergic H1, adrenergic α1, and dopaminergic D2 receptors. Reboxetine mesylate preventes the Dexamethasone-induced decreases in cell viability and proliferation rate. Cell Viability Assay Cell line: SH-SY5Y cells. Concentration: 0.1 μM, 1 μM, 5 μM Incubation time: 24 hours. Result: Prevented the Dexamethasone-induced decreases in cell viability and proliferation rate.

Storage & Handling

• Storage: Storage temperature: -20°C. Stability: ≥ 2 years
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

Davedax | Edronax | FCE 20124 | PNU 155950E

Quick Database Links

Gene Symbol

Norepinephrine