RCM-1

SKU: orb1307811

Description

RCM-1

Research Area

Cell Biology

Key Properties

• CAS Number: 339163-65-4
• MW: 424.58
• Purity: 99.89% (May vary between batches)
• Formula: C₂₀H₁₂N₂OS₄
• SMILES: O=C(CSc1nc(cc(-c2cccs2)c1C#N)-c1cccs1)c1cccs1
• Target: Others,DNA/RNA Synthesis
• Solubility: DMSO:16.67 mg/mL (39.26 mM)

Bioactivity

• In Vivo:
  RCM-1 decreases the B 16-FlO tumor growth as compared to the Vehicle -treated group. RCM-1 treatment decreases tumor cell proliferation and increased apoptosis in B16-FlO melanoma tumors. RCM-1 treatment reduces the growth of the human H2122 lung adenocarcinoma in mice. RCM-1 treatment reduces tumor cell proliferation and increases apoptosis in Rd76-9 rhabdomyosarcoma tumors. RCM-1 treatment decreases the growth of Rd76-9 rhabdomyosarcomas in mice. The RCM-1-treated Rd76-9 tumors display reduced FOXM1 staining and decreased expression of proliferation-specific markers Ki67 and PH3. Cleaved caspase staining is increased in the RCM-1 treated tumors, indicating an increase in apoptosis. RCM-1 treatment reduces the growth of B16-FlO melanoma tumors in mice .
• In Vitro:
  RCM-1 inhibits cellular proliferation via the increasing duration of cell cycle and mitosis in human and mouse cancer cell lines in vitro. RCM-1 inhibits colony formation of cancer cells in vitro in a dose-dependent manner. RCM-1 inhibits the migration of cancer cells in vitro in a dose-dependent manner. RCM-1 inhibits the initiation as well as the growth of cancer cell colonies in vitro. Treatment with RCM-1 increases the duration of mitosis and cell cycle in the cancer cell lines .

Storage & Handling

• Storage: Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

RCM 1, RCM-1, RCM1, FOXM1, Inhibitor, inhibit

Compound Identifiers

PubChem CID

4273985