RBPJ Inhibitor-1

SKU: orb1694506

Description

RBPJ Inhibitor-1 (RIN1) is a small molecule that disrupts the RBPJ-SHARP interaction, thereby blocking canonical NOTCH signaling and proliferation in tumor cells. It serves as a valuable research tool for investigating NOTCH pathway biology in both cellular and animal models of cancer and other diseases.

Research Area

Neuroscience, Pharmacology & Drug Discovery, Protein Biochemistry, Stem Cell & Developmental Biology

Key Properties

• CAS Number: 2682114-39-0
• MW: 311.31
• Purity: 99.79% (May vary between batches)
• Formula: C₁₇H₁₄FN₃O₂
• SMILES: O(C1=C(C(N)=O)C=CC(=C1)C=2N(C)N=CC2)C3=C(F)C=CC=C3
• Target: Gamma-secretase
• Solubility: 10% DMSO+40% PEG300+5% Tween 80+45% Saline:5 mg/mL (16.06 mM);DMSO:225 mg/mL (722.75 mM)

Bioactivity

• In Vitro:
  RBPJ Inhibitor-1 (RIN1) (2 μM) induced changes in gene expression that resembled siRNA silencing of RBPJ rather than inhibition at the level of NOTCH itself. Consistent with the disruption of NOTCH signaling, RIN1 (0.6 μM) inhibited the proliferation of hematologic cancer cell lines and promoted skeletal muscle differentiation from C2C12 myoblasts. Thus, RIN1 inhibits RBPJ in its repressing and activating contexts and can be exploited for chemical biology and therapeutic applications.
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Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

Notch, Gammasecretase, RIN 1, RIN1, RIN-1, RBPJ Inhibitor-1

Compound Identifiers

PubChem CID

146019721