Rbin-1

SKU: orb1220386

Description

Rbin-1 is a potentspecific inhibitor of eukaryotic ribosome biogenesis.

Key Properties

• CAS Number: 328023-11-6
• MW: 256.33
• Purity: >98% (HPLC)
• Formula: C₁₃H₁₂N₄S
• SMILES: C=C(C)CSc1nnc2c(n1)[nH]c1ccccc12
• Target: ATPase
• Solubility: DMSO:31 mg/mL (120.94 mM)

Bioactivity

• In Vitro:
  Rbin-1 is a potent and reversible triazinoindole-based inhibitors of eukaryotic ribosome biogenesis. Rbin-1 inhibits recombinant full-length Mdn1’s ATPase activity. Two of the active analogs (Rbin-1 and Rbin-2) inhibit the ATPase activity by 40% at 1 uM. In particular, an analog (Rbin-2) with a bromine substituent at postion-7 is 10-fold more active than Rbin-1 (GI50 = 14±1 nM (Rbin-2); 136±7 nM (Rbin-1), n=4, mean±SD).

Storage & Handling

• Storage: Storage temperature: -20°C. Stability: ≥ 2 years
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

Ribozinoindole-1

Quick Database Links

Gene Symbol

ATPase