Razuprotafib sodium

SKU: orb3174790

Description

Razuprotafib (AKB-9778) sodium is a potent and selective inhibitor of VE-PTP (HPTPη) catalytic activity, with an IC50 of 17 pM. It promotes TIE2 activation, enhances ANG1-induced TIE2 activation, and stimulates phosphorylation of signaling molecules in the TIE2 pathway, including AKT, eNOS, and ERK. Razuprotafib sodium also inhibits the structurally related phosphatase PTP1B with an IC50 of 780 nM. Additionally, apart from HPTPη (IC50 of 36 pM) and HPTPγ (100 pM), it has good selectivity for VE-PTP.

Key Properties

• CAS Number: 1809275-69-1
• MW: 610.69
• Formula: C₂₆H₂₇N₄NaO₆S₃
• SMILES: [C@@H](CC1=CC=C(NS(=O)(=O)O)C=C1)(NC([C@H](CC2=CC=CC=C2)NC(OC)=O)=O)C=3N=C(SC3)C4=CC=CS4.[Na]
• Target: Phosphatase,Tie-2

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Quick Database Links

Gene Symbol

Phosphatase,Tie-2