Rat CA125 Protein, His Tag (MALS verified)

SKU: orb2999610

Description

The CA125, also known as the MUC16, is a mucin protein that may be found in type I transmembrane or secreted forms that are used monitor the progress of epithelial ovarian cancer therapy. The CA 125 molecule is almost certainly a glycoprotein with a predominance of O-linkages. It is heterogeneous with regard to both size and charge, most likely due to continuous deglycosylation of side chains during its life-span in bodily fluids. It exists as a very large complex (perhaps as much as 4 million daltons) under natural conditions.

Research Area

Cancer Biology; Immunology & Inflammation

Images & Validation

• Application Notes:
  This protein carries a polyhistidine tag at the C-terminus. The protein has a calculated MW of 77.2 kDa. The protein migrates as 33-45 kDa and 90-130 kDa when calibrated against Star Ribbon Pre-stained Protein Marker under reducing (R) condition (SDS-PAGE) due to glycosylation.

Key Properties

• Expression System: HEK293
• Target: CA125
• Reactivity: Rat
• Tag: C-10×His
• Expression Region: Asn 8776 - Pro 9448
• Conjugation: Unconjugated
• MW: 77.2 kDa
• Purity: 90%

Storage & Handling

• Storage: -20°C
• Form/Appearance: Powder
• Buffer/Preservatives: PBS, pH 7.4
• Expiration Date: 6 months from date of receipt.
• Disclaimer: For research use only

Quick Database Links

Gene Symbol

CA125

UniProt

XP_063122364.1

RefSeq:XP_063122364.1