Rasarfin

SKU: orb1298113

Description

Rasarfin is a dual inhibitor targeting both Ras and ARF6 GTPases. It is a valuable research tool for studying oncogenic signaling and cellular trafficking pathways in cancer biology, with applications in both in vitro and in vivo experimental models.

Research Area

Pharmacology & Drug Discovery, Signal Transduction

Key Properties

• CAS Number: 674359-73-0
• MW: 425.91
• Purity: 98.58%
• Formula: C₂₃H₂₄ClN₃O₃
• SMILES: CC(C)C(=O)N1CCN(CC1)c1ccc(NC(=O)c2cc3ccccc3o2)cc1Cl
• Target: Ras
• Solubility: DMSO:60 mg/mL (140.87 mM)

Bioactivity

• In Vitro:
  Rasarfin resulted in a dose-dependent reduction in cell growth in MDA-MB-231 cells.After 48 and 72 h of treatment, Rasarfin modestly decreased in a dose-dependent manner the metabolic activity of cancer cells compared to cells treated with DMSO.However, compared to Doxorubicin which potently killed cells, cell viability was not affected by Rasarfin treatment. Rasarfin inhibited proliferation of A549 lung cancer cells, which have increased Ras and EGFR activity52. Similar to the anti-proliferative effect on MDA-MB-231 cells, A549 cell growth inhibition at 5 and 10 μM of Rasarfin,more important cell viability effects of Rasarfin on A549 cells than MDA-MB-231 cells at 10 μM of Rasarfin treatment.

Storage & Handling

• Storage: Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

inhibit, Inhibitor, internalization, negative, GPCR, ARF6, cancer, breast, Rasarfin, Ras, TNBC, triple

Compound Identifiers

PubChem CID

1396167