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RAS inhibitor Abd-7
Catalog Number: orb1693564
| Catalog Number | orb1693564 |
|---|---|
| Category | Small Molecules |
| Description | RAS inhibitor Abd-7 |
| CAS Number | 2351843-48-4 |
| Purity | 98.00% |
| MW | 391.46 |
| SMILES | COc1nc(ccc1Nc1ccc(CN(C)C)cc1)-c1cccc2OCCOc12 |
| Formula | C23H25N3O3 |
| Biological Activity | RAS inhibitor Abd-7 is a powerful compound (Kd=51 nM) that binds to RAS and inhibits the protein-protein interaction (PPI) between RAS and its effectors. By interacting with RAS within cells, RAS inhibitor Abd-7 hinders RAS-effector interactions and suppresses endogenous RAS-dependent signaling. Additionally, RAS inhibitor Abd-7 disrupts the PPI of different mutant KRAS proteins with PI3K, CRAF, RALGDS, as well as NRAS Q61H and HRAS G12V[1]. |
| Storage | -20°C |
| Note | For research use only |
| Expiration Date | 12 months from date of receipt. |
