Rapastinel acetate

SKU: orb1304230

Description

Rapastinel acetate is a glycine-site partial agonist of the NMDA receptor, exhibiting long-lasting antidepressant-like properties. It is utilized in neuroscience research to investigate glutamatergic signaling, synaptic plasticity, and mechanisms of antidepressant action in both in vitro and in vivo experimental models.

Research Area

Neuroscience, Pharmacology & Drug Discovery

Key Properties

• CAS Number: 491872-39-0
• MW: 473.52
• Purity: 99.60% (May vary between batches)
• Formula: C₂₀H₃₅N₅O₈
• SMILES: C(C)(O)=O.C(=O)([C@H]1N(C([C@H]([C@@H](C)O)N)=O)CCC1)N2[C@H](C(N[C@@H]([C@@H](C)O)C(N)=O)=O)CCC2
• Target: NMDAR,iGluR
• Solubility: DMSO:22.5 mg/mL (47.52 mM)

Bioactivity

• In Vivo:
  Rapastinel acetate (3mg/kg; i.v.) facilitated long-term potentiation (LTP) 1day-2weeks but not 4weeks post-dosing. Biweekly dosing with Rapastinel acetate sustained this effect for at least 8weeks. A single dose of Rapastinel acetate increased the proportion of whole-cell NMDAR current contributed by NR2B-containing NMDARs in the hippocampus 1week post-dosing, which returned to baseline by 4weeks post-dosing.

Storage & Handling

• Storage: keep away from moisture | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

117928-94-6, 117928-94-6 Free base, NMDA receptor, iGluR, Rapastinel Acetate, Rapastinel acetate (117928-94-6 Free base)

Compound Identifiers

PubChem CID

126480238