RANKL-IN-2

SKU: orb3211504

Description

RANKL-IN-2 is an orally active RANKL inhibitor with Kd values of 3.21 μM in SPR and 4.625 μM in MST experiments. It disrupts the RANKL-RANK interaction by binding to RANKL and inhibits osteoclastogenesis through suppressing ROS, MAPK, and NF-κB pathways. In vitro, RANKL-IN-2 suppresses osteoclastogenesis by inhibiting RANKL-induced osteoclast formation, bone resorption, and osteoclast-specific gene and protein expression. Additionally, RANKL-IN-2 prevents bone loss in ovariectomized osteoporosis mouse models, making it useful for osteoporosis research.

Key Properties

• CAS Number: 2667022-87-7
• MW: 420.16
• Formula: C₁₇H₁₃BrN₂OSe
• SMILES: O=C(NC=1C=CC([Se]C2=CC=C(Br)C=C2)=C3C=CC=NC13)C
• Target: ROS,RANKL/RANK,p38 MAPK,NF-κB

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Quick Database Links

Gene Symbol

ROS,RANKL/RANK,p38 MAPK,NF-κB