RANKL-IN-1

SKU: orb3173202

Description

RANKL-IN-1 is a selective inhibitor of receptor activator of nuclear factor-κB ligand (RANKL), with a KD value of 7.6 μM. It shows inhibitory activity and selectivity in osteoclastogenesis, with an IC50 of 0.07 μM and a selectivity index (SI) of 82.57. By directly binding to RANKL, RANKL-IN-1 blocks the activation of RANKL-induced NF-κB and MAPK pathways. This compound is applicable in research on metabolic diseases such as osteoporosis.

Research Area

Immunology & Inflammation, Protein Biochemistry, Signal Transduction

Key Properties

• Target: JNK,MMP,ROS,ERK,RANKL/RANK,p38 MAPK,NF-κB

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Quick Database Links

Gene Symbol

JNK,MMP,ROS,ERK,RANKL/RANK,p38 MAPK,NF-κB