Ramiprilat

SKU: orb1685449

Description

Ramiprilat is the active metabolite of the ACE inhibitor ramipril, used in hypertension research. It is applied in both in vitro enzymatic assays and in vivo models to study the renin-angiotensin system and cardiovascular physiology.

Research Area

Metabolism Research

Key Properties

• CAS Number: 87269-97-4
• MW: 388.46
• Purity: 97.45% (May vary between batches)
• Formula: C₂₁H₂₈N₂O₅
• SMILES: C[C@H](N[C@@H](CCc1ccccc1)C(O)=O)C(=O)N1[C@H]2CCC[C@H]2C[C@H]1C(O)=O
• Target: Endogenous Metabolite,RAAS,Angiotensin-converting Enzyme (ACE),Drug Metabolite
• Solubility: DMSO:3.89 mg/mL (10.01 mM)

Bioactivity

• In Vitro:
  The angiotensin-converting enzyme inhibitor ramiprilat has a protective effect on isolated cardiac myocytes exposed to hypoxia/reoxygenation and that this effect is most likely related to a local action of bradykinin on the cardiac myocyte via the activation of the kinin B2 receptor.

Storage & Handling

• Storage: Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

Ramiprilat, Ramipril diacid, Endogenous Metabolite, heart failure, Inhibitor, high blood pressure, HOE 498 diacid, inhibit, orally active, Angiotensin-converting Enzyme (ACE), ACE, ACE inhibitor

Compound Identifiers

PubChem CID

5464096