RAI-20

SKU: orb3210731

Description

RAI-20 (H018) is an orally bioavailable dual inhibitor of JAK1 and JAK2, with IC50 values of 15.1 and 22.7 nM, respectively. It exhibits excellent pharmacokinetic properties, including plasma stability, systemic exposure, and a prolonged half-life. In a collagen-induced arthritis rat model, RAI-20 demonstrates significant anti-inflammatory and anti-arthritic activities, effectively reducing paw swelling volume and the arthritis index. RAI-20 serves as a useful compound for research into the pathogenesis of rheumatoid arthritis.

Key Properties

• CAS Number: 2549180-90-5
• MW: 448.53
• Formula: C₂₀H₂₁FN₄O₃S₂
• SMILES: N(C(=O)[C@@H]1[C@@H](F)C1)C2=CN3C(=CC=CC3=N2)C=4SC(CN5CCS(=O)(=O)CC5)=CC4
• Target: JAK

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Quick Database Links

Gene Symbol

JAK