RAF709

SKU: orb1303861

Description

RAF709 is a potent and selective small molecule inhibitor of Raf kinases, exhibiting sub-nanomolar IC50 values against c-Raf (0.5 nM) and b-Raf (1.8 nM). It is a valuable research tool for investigating the MAPK/ERK signaling pathway in both cellular and in vivo models of cancer and proliferative diseases.

Research Area

Signal Transduction

Key Properties

• CAS Number: 1628838-42-5
• MW: 542.55
• Purity: 99.83% (May vary between batches)
• Formula: C₂₈H₂₉F₃N₄O₄
• SMILES: Cc1ncc(NC(=O)c2cccc(c2)C(F)(F)F)cc1-c1cnc(OC2CCOCC2)c(c1)N1CCOCC1
• Target: Raf
• Solubility: DMSO:91 mg/mL (167.73 mM);10% DMSO+40% PEG300+5% Tween 80+45% Saline:3.3 mg/mL (6.08 mM)

Bioactivity

• Target IC50:
  B-Raf:1.8 nM|C-Raf:0.5 nM
• In Vitro:
  The invention provides compounds (e.g., RAF709) that inhibit Raf kinases, and are accordingly useful for treating certain disorders associated with excessive Raf kinase activity, including cell proliferation disorders such as cancers.
  Read more...

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

C-Raf, B-Raf, Inhibitor, inhibit, Raf, RAF 709, Raf kinases, RAF709, RAF-709

Compound Identifiers

PubChem CID

90408826